Alzheimer's Disease (Pharmacology)

In this lecture we’re going to cover the pharmacology of drugs used in treatment of Alzheimer's disease , so let’s get right into it. Alzheimer’s disease is a progressive neurodegenerative disease that leads to symptoms of dementia. The pathophysiology of this disease is quite complex. However, there are currently few different hypotheses that try to explain the cause of Alzheimer’s. The most popular ones include:    (1) Cholinergic hypothesis, which states that a possible cause of Alzheimer’s is the loss of central cholinergic neurons and ensuing deficiency of acetylcholine, a neurotransmitter involved in memory and learning. (2) Amyloid hypothesis, which states that Alzheimer's may be caused by accumulation of abnormally folded beta-amyloid proteins. Beta-amyloid is a metabolic waste product present in the fluid between brain cells. In Alzheimer’s disease, beta-amyloid clumps together to form amyloid plaques, which are thought to induce Neuro inflammation and disrup